Premium
A Practical and General Base‐Catalyzed Carbonylation of Amines for the Synthesis of N ‐Formamides
Author(s) -
Li Wanfang,
Wu XiaoFeng
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201502107
Subject(s) - formamides , formylation , catalysis , carbonylation , chemistry , base (topology) , formamide , reagent , organic chemistry , organic base , base metal , combinatorial chemistry , materials science , carbon monoxide , mathematics , mathematical analysis , welding , metallurgy
A highly practical and general base‐catalyzed carbonylation of amines to the corresponding N ‐formamides has been realized. Cheap inorganic bases, including Group IA and IIA metal hydroxides, alkoxides, carbonates, and phosphates, were effective catalysts for the transformation. In the presence of 10–40 mol % of KOH or K 2 CO 3 , various amines were converted into the corresponding N ‐formamides in good‐to‐excellent yields using CO as the formylation reagents.