A Practical and General Base‐Catalyzed Carbonylation of Amines for the Synthesis of  N ‐Formamides | Zendy

Li Wanfang | Zendy; Wu XiaoFeng | Zendy

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A Practical and General Base‐Catalyzed Carbonylation of Amines for the Synthesis of N ‐Formamides

Author(s) -

Li Wanfang,

Wu XiaoFeng

Publication year - 2015

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201502107

Subject(s) - formamides , formylation , catalysis , carbonylation , chemistry , base (topology) , formamide , reagent , organic chemistry , organic base , base metal , combinatorial chemistry , materials science , carbon monoxide , mathematics , mathematical analysis , welding , metallurgy

A highly practical and general base‐catalyzed carbonylation of amines to the corresponding N ‐formamides has been realized. Cheap inorganic bases, including Group IA and IIA metal hydroxides, alkoxides, carbonates, and phosphates, were effective catalysts for the transformation. In the presence of 10–40 mol % of KOH or K 2 CO 3 , various amines were converted into the corresponding N ‐formamides in good‐to‐excellent yields using CO as the formylation reagents.

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