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Metal–Organic Frameworks (MOFs) as Multivalent Materials: Size Control and Surface Functionalization by Monovalent Capping Ligands
Author(s) -
Rijnaarts Timon,
MejiaAriza Raquel,
Egberink Richard J. M.,
van Roosmalen Wies,
Huskens Jurriaan
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201501974
Subject(s) - surface modification , ligand (biochemistry) , ethylene glycol , metal organic framework , chemistry , particle size , carboxylic acid , streptavidin , metal , peg ratio , combinatorial chemistry , materials science , nanotechnology , inorganic chemistry , polymer chemistry , organic chemistry , adsorption , biotin , biochemistry , receptor , finance , economics
Control over particle size and composition are pivotal to tune the properties of metal organic frameworks (MOFs), for example, for biomedical applications. Particle‐size control and functionalization of MIL‐88A were achieved by using stoichiometric replacement of a small fraction of the divalent fumarate by monovalent capping ligands. A fluorine‐capping ligand was used to quantify the surface coverage of capping ligand at the surface of MIL‐88A. Size control at the nanoscale was achieved by using a monovalent carboxylic acid‐functionalized poly(ethylene glycol) (PEG‐COOH) ligand at different concentrations. Finally, a biotin–carboxylic acid capping ligand was used to functionalize MIL‐88A to bind fluorescently labeled streptavidin as an example towards bioapplications.
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