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Coupling‐Reagent‐Free Synthesis of Dipeptides and Tripeptides Using Amino Acid Ionic Liquids
Author(s) -
Furukawa Shinya,
Fukuyama Takahide,
Matsui Akihiro,
Kuratsu Mai,
Nakaya Ryotaro,
Ineyama Takashi,
Ueda Hiroshi,
Ryu Ilhyong
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201501783
Subject(s) - tripeptide , reagent , chemistry , ionic liquid , amino acid , dipeptide , glycine , organic chemistry , combinatorial chemistry , peptide synthesis , coupling (piping) , chemical ligation , catalysis , biochemistry , materials science , metallurgy
A general method for the synthesis of dipeptides has been developed, which does not require any coupling reagents. This method is based on the reaction of readily available HCl salts of amino acid methyl esters with tetrabutylphosphonium amino acid ionic liquids. The isolation procedure of stepwise treatment with AcOH is easy to carry out. The method was extended to the synthesis of tripeptide, tyrosyl‐glycyl‐glycine, present in IMREG‐1, also.