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BODIPY: A Highly Versatile Platform for the Design of Bimodal Imaging Probes
Author(s) -
Lhenry Damien,
Larrouy Manuel,
Bernhard Claire,
Goncalves Victor,
Raguin Olivier,
Provent Peggy,
Moreau Mathieu,
Collin Bertrand,
Oudot Alexandra,
Vrigneaud JeanMarc,
Brunotte François,
Goze Christine,
Denat Franck
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201501676
Subject(s) - bodipy , bioconjugation , molecular imaging , in vivo , imaging agent , fluorescence lifetime imaging microscopy , fluorescence , nanotechnology , conjugated system , preclinical imaging , optical imaging , materials science , chemistry , organic chemistry , physics , microbiology and biotechnology , quantum mechanics , biology , polymer , optics
In molecular imaging, multimodal imaging agents can provide complementary information, for improving the accuracy of disease diagnosis or enhancing patient management. In particular, optical/nuclear imaging may find important preclinical and clinical applications. To simplify the preparation of dual‐labeled imaging agents, we prepared versatile monomolecular multimodal imaging probe (MOMIP) platforms containing both a fluorescent dye (BODIPY) and a metal chelator (polyazamacrocycle). One of the MOMIP was conjugated to a cyclopeptide (i.e., octreotide) and radiolabeled with 111 In. In vitro and in vivo studies of the resulting bioconjugate were conducted, highlighting the potential of these BODIPY‐based bimodal probes. This work also confirmed that the biovector and/or the bimodal probes must be chosen carefully, due to the impact of the MOMIP on the overall properties of the resulting imaging agent.