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Regiospecific Intermolecular Aminohydroxylation of Olefins by Photoredox Catalysis
Author(s) -
Miyazawa Kazuki,
Koike Takashi,
Akita Munetaka
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201501590
Subject(s) - vicinal , photoredox catalysis , photocatalysis , catalysis , chemistry , intermolecular force , organic chemistry , combinatorial chemistry , molecule
A simple and regiospecific aminohydroxylation of olefins by photoredox catalysis has been developed. N‐protected 1‐aminopyridinium salts are the key compounds and serve as amidyl radical precursors by the action of Ir photocatalysts, fac ‐[Ir(ppy) 3 ] and [Ir(ppy) 2 (dtbbpy)](PF 6 ) (ppy=2‐pyridylphenyl, dtbbpy=4,4′‐di‐ tert ‐butyl‐2,2′‐bipyridine). The present photocatalytic system allows for synthesis of vicinal aminoalcohol derivatives from olefins with various functional groups under mild reaction conditions with easy handling.