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Peptide δ‐Turn: Literature Survey and Recent Progress
Author(s) -
Toniolo Claudio,
Crisma Marco,
Moretto Alessandro,
Peggion Cristina,
Formaggio Fernando,
Alemán Carlos,
Cativiela Carlos,
Ramakrishnan Chandrasekharan,
Balaram Padmanabhan
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201501467
Subject(s) - turn (biochemistry) , business , chemistry , biochemistry
Among the various types of α‐peptide folding motifs, δ‐turn, which requires a central cis ‐amide disposition, has been one of the least extensively investigated. In particular, this main‐chain reversal topology has been studied in‐depth neither in linear/cyclic peptides nor in proteins. This Minireview article assembles and critically analyzes relevant data from a literature survey on the δ‐turn conformation in those compounds. Unpublished results from recent conformational energy calculations and a preliminary solution‐state analysis on a small model peptide, currently ongoing in our laboratories, are also briefly outlined.