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Catalytic CH Bond Addition of Pyridines to Allenes by a Rare‐Earth Catalyst
Author(s) -
Song Guoyong,
Wang Baoli,
Nishiura Masayoshi,
Hou Zhaomin
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201501121
Subject(s) - scandium , catalysis , pyridine , rare earth , cationic polymerization , chemistry , organic chemistry , combinatorial chemistry , mineralogy
The catalytic CH addition of pyridines to allenes has been achieved for the first time by using a half‐sandwich scandium catalyst, thus constituting a straightforward and atom‐economical route for the synthesis of alkenylated pyridine derivatives. The reaction proceeded regio‐ and stereoselectively, affording a new family of alkenylated pyridine compounds which are otherwise difficult to synthesize. A cationic Sc‐η 2 ‐pyridyl species was isolated and confirmed to be a key catalyst species in this transformation.