Carbon‐11 Radiolabelling of Organosulfur Compounds:  11 C Synthesis of the Progesterone Receptor Agonist Tanaproget | Zendy

Haywood Tom | Zendy; Kealey Steven | Zendy; SánchezCabezas Santiago | Zendy; Hall James J. | Zendy; Allott Louis | Zendy; Smith Graham | Zendy; Plisson Christophe | Zendy; Miller Philip W. | Zendy

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Carbon‐11 Radiolabelling of Organosulfur Compounds: 11 C Synthesis of the Progesterone Receptor Agonist Tanaproget

Author(s) -

Haywood Tom,

Kealey Steven,

SánchezCabezas Santiago,

Hall James J.,

Allott Louis,

Smith Graham,

Plisson Christophe,

Miller Philip W.

Publication year - 2015

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201501089

Subject(s) - synthon , chemistry , agonist , radioligand , organosulfur compounds , pet imaging , stereochemistry , combinatorial chemistry , positron emission tomography , receptor , organic chemistry , sulfur , biochemistry , nuclear medicine , medicine

Herein a new 11 C radiolabelling strategy for the fast and efficient synthesis of thioureas and related derivatives using the novel synthon, 11 CS 2 , is reported. This approach has enabled the facile labelling of a potent progesterone receptor (PR) agonist, [ 11 C]Tanaproget, by the intramolecular reaction of the acyclic aminohydroxyl precursor with 11 CS 2 , which has potential applications as a positron emission tomography radioligand for cancer imaging.

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