Premium
Transition‐Metal‐Free Trifluoromethylthiolation of N‐Heteroarenes
Author(s) -
Honeker Roman,
Ernst Johannes B.,
Glorius Frank
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201500957
Subject(s) - functional group , transition metal , combinatorial chemistry , chemistry , sodium , catalysis , organic chemistry , polymer
A general and efficient methodology for the direct transition metal free trifluoromethylthiolation of a broad range of biologically relevant N‐heteroarenes is reported employing abundant sodium chloride as the catalyst. This method is operationally simple, exhibits high functional group tolerance, and does not require protecting groups.