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Dynamic Formation of Noncovalent Calixsalen Aggregates
Author(s) -
Petryk Małgorzata,
Troć Anna,
Gierczyk Błażej,
Danikiewicz Witold,
Kwit Marcin
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201500945
Subject(s) - dimer , monomer , non covalent interactions , chemical physics , chemistry , nuclear magnetic resonance spectroscopy , diffusion , optical rotation , computational chemistry , polymer , molecule , stereochemistry , organic chemistry , thermodynamics , hydrogen bond , physics
A procedure for studying “dynamic structural behavior” of large chiral macrocycles is presented. Ion mobility MS, diffusion‐ordered NMR spectroscopy (DOSY NMR), and optical rotation (OR) measurements, supported by calculations, are used together as effective complementary methods to study dynamic formation of noncovalent aggregates. It is shown that the monomer–dimer equilibrium is driven by π–π or CH–π interactions and controlled largely by the substitution pattern of the calixsalen skeleton.