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Luminescence‐Functionalized Metal–Organic Frameworks Based on a Ruthenium(II) Complex: A Signal Amplification Strategy for Electrogenerated Chemiluminescence Immunosensors
Author(s) -
Xiong ChengYi,
Wang HaiJun,
Liang WenBin,
Yuan YaLi,
Yuan Ruo,
Chai YaQin
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201500909
Subject(s) - ruthenium , luminescence , chemiluminescence , electrochemiluminescence , detection limit , bioanalysis , metal organic framework , materials science , linear range , metal ions in aqueous solution , combinatorial chemistry , nanotechnology , metal , inorganic chemistry , chemistry , catalysis , chromatography , organic chemistry , optoelectronics , metallurgy , adsorption
Novel luminescence‐functionalized metal–organic frameworks (MOFs) with superior electrogenerated chemiluminescence (ECL) properties were synthesized based on zinc ions as the central ions and tris(4,4′‐dicarboxylicacid‐2,2′‐bipyridyl)ruthenium(II) dichloride ([Ru(dcbpy) 3 ] 2+ ) as the ligands. For potential applications, the synthesized MOFs were used to fabricate a “signal‐on” ECL immunosensor for the detection of N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP). As expected, enhanced ECL signals were obtained through a simple fabrication strategy because luminescence‐functionalized MOFs not only effectively increased the loading of [Ru(dcbpy) 3 ] 2+ , but also served as a loading platform in the ECL immunosensor. Furthermore, the proposed ECL immunosensor had a wide linear range from 5 pg mL −1 to 25 ng mL −1 and a relatively low detection limit of 1.67 pg mL −1 (signal/noise=3). The results indicated that luminescence‐functionalized MOFs provided a novel amplification strategy in the construction of ECL immunosensors and might have great prospects for application in bioanalysis.