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Palladium‐Catalyzed Oxidative Synthesis of Highly Functionalized Ortholactones
Author(s) -
Baddeley Kate L.,
Cao Qun,
Muldoon Mark J.,
Cook Matthew J.
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201500862
Subject(s) - chemoselectivity , palladium , catalysis , oxidative phosphorylation , wacker process , chemistry , combinatorial chemistry , functional group , oxidative addition , organic chemistry , biochemistry , polymer
A palladium‐catalyzed oxidative reaction is reported which converts dihydropyrans to their corresponding ortholactone. The products are formed in good to excellent yields with a very high level of chemoselectivity and functional group tolerance. Mechanistic studies confirm that the reaction proceeds by a Wacker‐type mechanism.