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Dienamine and Friedel–Crafts One‐Pot Synthesis, and Antitumor Evaluation of Diheteroarylalkanals
Author(s) -
Frías María,
Padrón José M.,
Alemán José
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201500660
Subject(s) - friedel–crafts reaction , indole test , aldehyde , nucleophile , chemistry , cancer cell lines , combinatorial chemistry , organic chemistry , stereochemistry , catalysis , cancer cell , cancer , biology , genetics
An asymmetric synthesis of diheteroarylalkanals through one‐pot dienamine and Friedel–Crafts reaction is presented. The reaction tolerates a large variety of substituents at different positions of the starting aldehyde and also in the indole nucleophile, and a range of diheterocyclic alkanals can be achieved. Furthermore, we have studied the antiproliferative activity of these new compounds in representative cancer tumor cell lines.