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Easy To Synthesize, Robust Organo‐osmium Asymmetric Transfer Hydrogenation Catalysts
Author(s) -
Coverdale James P. C.,
SanchezCano Carlos,
Clarkson Guy J.,
Soni Rina,
Wills Martin,
Sadler Peter J.
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201500534
Subject(s) - osmium , catalysis , transfer hydrogenation , denticity , chemistry , ruthenium , amine gas treating , ligand (biochemistry) , noyori asymmetric hydrogenation , enantioselective synthesis , electron transfer , crystal structure , combinatorial chemistry , polymer chemistry , organic chemistry , medicinal chemistry , biochemistry , receptor
Asymmetric transfer hydrogenation (ATH) is an important process in organic synthesis for which the Noyori‐type Ru II catalysts [(arene)Ru(Tsdiamine)] are now well established and widely used. We now demonstrate for the first time the catalytic activity of the osmium analogues. X‐ray crystal structures of the 16‐electron Os II catalysts are almost identical to those of Ru II . Intriguingly the precursor complex was isolated as a dichlorido complex with a monodentate amine ligand. The Os II catalysts are readily synthesised (within 1 h) and exhibit excellent enantioselectivity in ATH reactions of ketones.