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CBr 4 ‐Mediated Cross‐Dehydrogenative Coupling Reaction of Amines
Author(s) -
Huo Congde,
Xie Haisheng,
Wu Mingxia,
Jia Xiaodong,
Wang Xicun,
Chen Fengjuan,
Tang Jing
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201500453
Subject(s) - aromatization , chemistry , quinoline , nucleophile , coupling reaction , cascade reaction , glycine , tandem , combinatorial chemistry , aryl , reaction mechanism , reaction conditions , organic chemistry , biochemistry , catalysis , alkyl , materials science , amino acid , composite material
A novel CBr 4 ‐mediated dehydrogenative Povarov/aromatization tandem reaction of glycine derivatives with alkenes, leading to complex quinoline derivatives, and a CBr 4 ‐mediated dehydrogenative CH functionalization of N ‐aryl tetrahydroisoquinolines with nucleophiles to form CC and CP bonds are reported. The reactions were performed under very simple and mild reaction conditions; only CBr 4 was used as a promoter. A plausible mechanism involving a radical process is proposed.