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Triggering the Directional Selectivity of a Ring‐Closure Reaction Leads to Pyridoazacarbazoles with Anticancer Properties
Author(s) -
Steinhauer Tamara N.,
Längle Daniel S.,
Meier Christopher,
Girreser Ulrich,
Stenzel Lars,
Heber Dieter,
Clement Bernd
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201500156
Subject(s) - closure (psychology) , combinatorial chemistry , ring (chemistry) , selectivity , substitution (logic) , chemistry , computer science , catalysis , organic chemistry , programming language , economics , market economy
We herein describe a facile and versatile synthetic route to the tetracyclic system of 6‐substituted 5,6‐dihydro‐11 H ‐pyrido[3,2‐ i ]‐1‐azacarbazoles with promising anticancer properties. These derivatives are built up by an elegant one‐step base‐catalyzed synthetic procedure from commercially available building blocks. One additional step provides the corresponding skeleton hitherto unknown in the literature. The possibility to synthesize a large library of compounds with various substitution patterns utilizing this method underlines the importance of this synthetic procedure.