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Inside Cover: Protonation of a Biologically Relevant Cu II μ‐Thiolate Complex: Ligand Dissociation or Formation of a Protonated Cu I Disulfide Species? (Chem. Eur. J. 51/2014)
Author(s) -
OrdingWenker Erica C. M.,
van der Plas Martijn,
Siegler Maxime A.,
Fonseca Guerra Célia,
Bouwman Elisabeth
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201490211
Subject(s) - protonation , chemistry , dissociation (chemistry) , redox , copper , ligand (biochemistry) , metal , disulfide bond , crystallography , photochemistry , inorganic chemistry , stereochemistry , ion , organic chemistry , biochemistry , receptor
Protonation of a Cu II μ‐thiolate complex induces an internal redox reaction by which a Cu I disulfide compound is formed. The dinuclear Cu II μ‐thiolate species forms a model for the CuA site, which has been shown to be sensitive to pH changes. In their Full Paper on page 16913 ff., C. Fonseca Guerra, E. Bouwman et al. show, both experimentally and computationally, that, after addition of just one equivalent of acid per copper center, not only does this redox reaction occur, but ligand dissociation takes place as well. The results imply that pH can have a tremendous effect on the coordination environment of the metal center.