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Back Cover: 2‐Methoxy‐4‐methylsulfinylbenzyl: A Backbone Amide Safety‐Catch Protecting Group for the Synthesis and Purification of Difficult Peptide Sequences (Chem. Eur. J. 46/2014)
Author(s) -
ParadísBas Marta,
TullaPuche Judit,
Albericio Fernando
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201490193
Subject(s) - peptide , trifluoroacetic acid , cleavage (geology) , amide , protecting group , chemistry , combinatorial chemistry , cover (algebra) , elongation , stereochemistry , biochemistry , organic chemistry , biology , materials science , engineering , paleontology , alkyl , fracture (geology) , mechanical engineering , ultimate tensile strength , metallurgy
2‐Methoxy‐4‐methylsulfinylbenzyl (Mmsb) is a new backbone amide‐protecting group based on the safety‐catch concept. Mmsb is stable during the elongation of the peptide sequence and to trifluoroacetic acid cleavage from the resin. The presence of Mmsb reduces intra‐ and inter‐chain interactions and thereby improves the synthetic process, as well as the properties of the quasi‐unprotected peptide. Mmsb offers the possibility to purify and characterize complex peptide sequences before the final cleavage that renders the target peptide. For more details, see the Full Paper by F. Albericio, J. Tulla‐Puche, and Paradís‐Bas on page 15031 ff.