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Cover Picture: Quantitative Description of Structural Effects on the Stability of Gold(I) Carbenes (Chem. Eur. J. 44/2014)
Author(s) -
Ringger David H.,
Kobylianskii Ilia J.,
Serra Daniel,
Chen Peter
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201490182
Subject(s) - thiourea , catalytic cycle , chemistry , catalysis , cyclopropanation , carbene , rhodium , molecule , organometallic chemistry , computational chemistry , combinatorial chemistry , organic chemistry
De novo design of a catalytic cycle represents a great challenge for organic and organometallic chemistry. Turnover requires the optimization of multiple elementary steps, all within the boundaries of structurally realizable molecules. In their Full Paper on page 14270 ff. Chen and co‐workers report the mechanistic studies of a gold‐catalyzed cyclopropanation reaction, in which a novel imidazolium sulfone serves as a carbene donor, as well as the source of a base needed to turn over the catalytic cycle. The effect of substitution on the elementary rates is determined experimentally in the gas phase and in solution, accompanied by DFT calculations.