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Inside Cover: The Multicomponent Hantzsch Reaction: Comprehensive Mass Spectrometry Monitoring Using Charge‐Tagged Reagents (Chem. Eur. J. 40/2014)
Author(s) -
Santos Vanessa G.,
Godoi Marla N.,
Regiani Thaís,
Gama Fernando H. S.,
Coelho Mirela B.,
de Souza Rodrigo O. M. A.,
Eberlin Marcos N.,
Garden Simon J.
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201490167
Subject(s) - reagent , protonation , chemistry , mass spectrometry , combinatorial chemistry , medicinal chemistry , ion , organic chemistry , chromatography
Exocoetidae The zoomorphism portrays the ESI‐MS(/MS) fishing of the permanently charge‐tagged (CT) reagents and their subsequent intermediates and products. The use of the CT reagents allows reaction monitoring under real reaction conditions without the requirement for ESI additives or adventitious equilibria for (de)protonation or ion association and provides a powerful means for identifying intermediates, their transformations, and the delineation of reaction pathways within the multi‐component Hantzsch 1,4‐dihydropyridine reaction. For more information, see the Full Paper by M. N. Eberlin, S. J. Garden et al. on page 12808 ff. Artwork by Nicolas V. Schwab, Chemistry Institute, UNICAMP, SP, Brazil.