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Cover Picture: A Glutathione‐Activated Phthalocyanine‐Based Photosensitizer for Photodynamic Therapy (Chem. Eur. J. 21/2014)
Author(s) -
He Hui,
Lo PuiChi,
Ng Dennis K. P.
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201490083
Subject(s) - photosensitizer , photodynamic therapy , reactive oxygen species , chemistry , glutathione , phthalocyanine , photochemistry , cancer research , biophysics , medicine , biochemistry , organic chemistry , enzyme , biology
Smart photosensitizers that can be activated selectively by tumor‐associated stimuli are of great potential for targeted photodynamic therapy. They can enhance the overall therapeutic outcome and reduce undesirable side effects. In their Communication on page 6241 ff., H. He, P.‐C. Lo, and D. K. P. Ng report a simple, yet highly efficient, phthalocyanine‐based photosensitizer. Its fluorescence emission and reactive oxygen species generation are greatly enhanced by glutathione, both in phosphate‐buffered saline and inside cancer cells. The activation of this photosensitizer has also been demonstrated in tumor‐bearing nude mice.