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Frontispiece: Lead Structures for New Antibacterials: Stereocontrolled Synthesis of a Bioactive Muraymycin Analogue
Author(s) -
Spork Anatol P.,
Büschleb Martin,
Ries Oliver,
Wiegmann Daniel,
Boettcher Stefan,
Mihalyi Agnes,
Bugg Timothy D. H.,
Ducho Christian
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201484761
Subject(s) - antibiotics , antimicrobial , lead compound , combinatorial chemistry , modular design , chemistry , lead (geology) , derivative (finance) , nucleoside , stereochemistry , computational biology , biology , computer science , organic chemistry , biochemistry , business , programming language , paleontology , finance , in vitro
Medicinal Chemistry Natural products and their analogues are particularly important for the development of novel antimicrobial agents. In their Communication on page 15292 ff., Ducho and co‐workers report on the efficient modular and stereocontrolled synthesis of a structurally simplified derivative of naturally occurring muraymycin nucleoside antibiotics. The obtained target compound showed promising biological properties and can, therefore, serve as a lead structure for future research on new antibacterials.