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Frontispiece: Palladium‐Catalysed Direct Cross‐Coupling of Organolithium Reagents with Aryl and Vinyl Triflates
Author(s) -
Vila Carlos,
Hornillos Valentín,
Giannerini Massimo,
FañanásMastral Martín,
Feringa Ben L.
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201484171
Subject(s) - aryl , palladium , reagent , trifluoromethanesulfonate , catalysis , chemistry , alkyl , organolithium compounds , combinatorial chemistry , halide , coupling reaction , carbon fibers , organic synthesis , organic chemistry , polymer chemistry , materials science , ion , composite number , deprotonation , composite material
Carbon–Carbon Bond Formation Carbon–carbon bond formation by the cross‐coupling of highly reactive organolithium reagents is a major challenge. Recently, it was demonstrated that palladium catalysts are able to couple organic halides with various organolithium species under mild conditions in a highly selective transformation. In their Communication on page 13078 ff., B. L. Feringa et al. present a catalytic system for the palladium‐catalyzed cross‐coupling of aryl and alkenyl triflates with a range of alkyl and aryllithium reagents. This transformation allows the direct use of organolithium compounds and features short reaction times, thereby providing a viable alternative to current triflate‐based cross‐coupling methodology.