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In Situ Formation of Dual‐Phase Thermosensitive Ultrasmall Gold Nanoparticles
Author(s) -
He Zidong,
Zhong Aiqing,
Zhang Hui,
Xiong Linfeng,
Xu Yang,
Wang Tianqi,
Zhou Minghong,
Huang Kun
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201406670
Subject(s) - methacrylamide , colloidal gold , copolymer , amphiphile , in situ , materials science , aqueous solution , nanoparticle , chloroform , phase (matter) , polymer chemistry , chemical engineering , phase transition , nanotechnology , chemistry , organic chemistry , polymer , composite material , acrylamide , physics , quantum mechanics , engineering
A novel method for the in situ synthesis of dual‐phase thermosensitive ultrasmall gold nanoparticles (USGNPs) with diameters in the range of 1–3 nm was developed by using poly( N ‐isopropylacrylamide)‐ block ‐poly( N ‐phenylethylenediamine methacrylamide) (PNIPAM‐ b ‐PNPEDMA) amphiphilic diblock copolymers as ligands. The PNPEDMA block promotes the in situ reduction of gold precursors to zero‐valent gold and subsequently binds to the surface of gold nanoparticles, while PNIPAM acts as a stabilizing and thermosensitive block. The as‐synthesized USGNPs stabilized by a thermosensitive PNIPAM layer exhibit a sharp, reversible, clear–opaque transition in aqueous solution between 30 and 38 °C. An unprecedented finding is that these USGNPs also show a reversible soluble–precipitate transition in nonpolar organic solvents such as chloroform at around 0 °C under acidic conditions.
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