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Practical Synthesis of [ n ]Cycloparaphenylenes ( n =5, 7–12) by H 2 SnCl 4 ‐Mediated Aromatization of 1,4‐Dihydroxycyclo‐2,5‐diene Precursors
Author(s) -
Patel Vijay Kumar,
Kayahara Eiichi,
Yamago Shigeru
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201406650
Subject(s) - aromatization , chemistry , stoichiometry , decomposition , catalysis , phenylene , diene , medicinal chemistry , organic chemistry , polymer , natural rubber
Cyclic precursors of cycloparaphenylenes (CPPs) containing 1,4‐dihydroxy‐2,5‐cyclohexadien‐1,4‐diyl units are prepared by modifying a synthetic method developed by Jasti and co‐workers for the synthesis of corresponding 1,4‐dimethoxy derivatives. Reductive aromatization of the diyl moieties by SnCl 2 /2 HCl takes place under mild conditions and affords the CPPs in good yields, incorporating 5 or 7–12 phenylene units. Highly strained [5]CPP is synthesized in greater than 0.3 g scale. 119 Sn NMR spectroscopy clarifies the in situ formation of an ate complex, H 2 SnCl 4 , upon mixing a 2:1 ratio of HCl and SnCl 2 , which serves as a highly active reducing agent under nearly neutral conditions. When more than 2 equivalents of HCl, in relation to SnCl 2 , are used, acid‐catalyzed decomposition of the CPP precursors takes place. The stoichiometry of HCl and SnCl 2 is critical in achieving the desired aromatization reaction of highly strained CPP precursors.