Regio‐ and Chemoselective N‐1 Acylation of Indoles: Pd‐Catalyzed Domino Cyclization to Afford 1,2‐Fused Tricyclic Indole Scaffolds | Zendy

Liu Yongxian | Zendy; Huang Yuanqiong | Zendy; Song Hongjian | Zendy; Liu Yuxiu | Zendy; Wang Qingmin | Zendy

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Regio‐ and Chemoselective N‐1 Acylation of Indoles: Pd‐Catalyzed Domino Cyclization to Afford 1,2‐Fused Tricyclic Indole Scaffolds

Author(s) -

Liu Yongxian,

Huang Yuanqiong,

Song Hongjian,

Liu Yuxiu,

Wang Qingmin

Publication year - 2015

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201406617

Subject(s) - indole test , tricyclic , sonogashira coupling , chemistry , domino , acylation , combinatorial chemistry , catalysis , stereochemistry , organic chemistry , palladium

A concise method for the synthesis of 1,2‐fused tricyclic indole scaffolds by domino cyclization involving a Pd‐catalyzed Sonogashira coupling, indole cyclization, regio‐ and chemoselective N‐1 acylation, and 1,4‐Michael addition is reported. This method provides straightforward access to tetrahydro[1,4]diazepino[1,2‐ a ]indole and hexahydro[1,5]diazocino[1,2‐ a ]indole scaffolds.

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