Pd‐Catalyzed Csp 2 H Functionalization of Heteroarenes via Isocyanide Insertion: Concise Synthesis of Di‐(Hetero)Aryl Ketones and Di‐(Hetero)Aryl Alkylamines | Zendy

Sharma Upendra K. | Zendy; Sharma Nandini | Zendy; Xu Jun | Zendy; Song Gonghua | Zendy; Van der Eycken Erik V. | Zendy

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Pd‐Catalyzed Csp 2 H Functionalization of Heteroarenes via Isocyanide Insertion: Concise Synthesis of Di‐(Hetero)Aryl Ketones and Di‐(Hetero)Aryl Alkylamines

Author(s) -

Sharma Upendra K.,

Sharma Nandini,

Xu Jun,

Song Gonghua,

Van der Eycken Erik V.

Publication year - 2015

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201406562

Subject(s) - isocyanide , aryl , surface modification , chemistry , imine , catalysis , azole , combinatorial chemistry , hydrolysis , medicinal chemistry , organic chemistry , antifungal , medicine , alkyl , dermatology

We report herein an efficient Pd‐catalyzed direct CH bond functionalization of heteroarenes via an isocyanide insertion strategy for the synthesis of di‐(hetero)aryl ketones and di‐(hetero)aryl alkylamines. The methodology involves a three component reaction between an azole, a haloarene and an isocyanide resulting in the formation of an imine, which in turn is either hydrolyzed or reduced to get the desired product.

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