Asymmetric Suzuki–Miyaura Cross‐Coupling for the Synthesis of Chiral Biaryl Compounds as Potential Monophosphine Ligands | Zendy

Ma YanNa | Zendy; Yang ShangDong | Zendy

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Asymmetric Suzuki–Miyaura Cross‐Coupling for the Synthesis of Chiral Biaryl Compounds as Potential Monophosphine Ligands

Author(s) -

Ma YanNa,

Yang ShangDong

Publication year - 2015

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201406554

Subject(s) - phosphinate , chemistry , combinatorial chemistry , coupling (piping) , enantioselective synthesis , coupling reaction , catalysis , organic chemistry , materials science , fire retardant , metallurgy

Efficient asymmetric Suzuki–Miyaura coupling reactions have been employed for the first time to synthesize chiral biaryl compounds with phosphinate groups as chiral auxiliaries. A series of functionalized chiral biaryls are thereby synthesized in excellent yields and good diastereoselectivities (up to >95:5 d.r.) and axially chiral monophosphorus ligands are obtained through further functionalizations.

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