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Asymmetric Suzuki–Miyaura Cross‐Coupling for the Synthesis of Chiral Biaryl Compounds as Potential Monophosphine Ligands
Author(s) -
Ma YanNa,
Yang ShangDong
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201406554
Subject(s) - phosphinate , chemistry , combinatorial chemistry , coupling (piping) , enantioselective synthesis , coupling reaction , catalysis , organic chemistry , materials science , fire retardant , metallurgy
Efficient asymmetric Suzuki–Miyaura coupling reactions have been employed for the first time to synthesize chiral biaryl compounds with phosphinate groups as chiral auxiliaries. A series of functionalized chiral biaryls are thereby synthesized in excellent yields and good diastereoselectivities (up to >95:5 d.r.) and axially chiral monophosphorus ligands are obtained through further functionalizations.