Premium
Calcium‐Catalyzed Carboarylation of Alkynes
Author(s) -
Fu Liang,
Niggemann Meike
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201406503
Subject(s) - catalysis , functional group , scope (computer science) , calcium , substrate (aquarium) , reaction conditions , chemistry , combinatorial chemistry , organic chemistry , computer science , biology , ecology , programming language , polymer
The first transition‐metal‐free carboarylation of alkynes with commercial and readily available alcohols as alkylating agents was realized in the presence of an environmentally benign calcium catalyst. Thereby, a novel protocol for the one‐step synthesis of highly congested, all‐carbon tetrasubstituted alkenes, as incorporated in potentially bioactive, complex dihydronaphthalene, chromene and dihydroquinoline structures, is provided. The reaction features an unprecedented, particularly wide substrate scope, good functional‐group tolerance and simple experimental operation under mild reaction conditions.