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Synthetic Studies on Actinorhodin and γ‐Actinorhodin: Synthesis of Deoxyactinorhodin and Deoxy‐γ‐actinorhodin/Crisamicin A Isomer
Author(s) -
Mulay Sandip V.,
Fernandes Rodney A.
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201406431
Subject(s) - actinorhodin , biology , stereochemistry , chemistry , polyketide , biosynthesis , biochemistry , gene
A strategy based on bidirectional Dötz benzannulation and the oxa‐Pictet–Spengler reaction toward the synthesis of actinorhodin and γ‐actinorhodin has been explored. This work has resulted in the synthesis of deoxyactinorhodin and deoxy‐γ‐actinorhodin. The latter is a regioisomer of crisamicin A (which has 10,10′‐dihydroxy groups).