Hypervalent‐Iodine‐Mediated Cascade Annulation of Diarylalkynes Forming Spiro Heterocycles under Metal‐Free Conditions | Zendy

Zhang Xiang | Zendy; Yang Chao | Zendy; ZhangNegrerie Daisy | Zendy; Du Yunfei | Zendy

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Hypervalent‐Iodine‐Mediated Cascade Annulation of Diarylalkynes Forming Spiro Heterocycles under Metal‐Free Conditions

Author(s) -

Zhang Xiang,

Yang Chao,

ZhangNegrerie Daisy,

Du Yunfei

Publication year - 2015

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201406393

Subject(s) - hypervalent molecule , annulation , iodine , reagent , cascade , chemistry , metal , combinatorial chemistry , organic chemistry , catalysis , chromatography

An unusual reaction featuring the cascade annulation of internal alkynes to afford spiro heterocycles as the products has been realized for the first time with a hypervalent iodine reagent as the only oxidant. This unprecedented process encompasses not only two sequential CN/CO‐bond formations, but also the insertion of a carbonyl oxygen, all in one pot under metal‐free conditions.

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