Premium
Hypervalent‐Iodine‐Mediated Cascade Annulation of Diarylalkynes Forming Spiro Heterocycles under Metal‐Free Conditions
Author(s) -
Zhang Xiang,
Yang Chao,
ZhangNegrerie Daisy,
Du Yunfei
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201406393
Subject(s) - hypervalent molecule , annulation , iodine , reagent , cascade , chemistry , metal , combinatorial chemistry , organic chemistry , catalysis , chromatography
An unusual reaction featuring the cascade annulation of internal alkynes to afford spiro heterocycles as the products has been realized for the first time with a hypervalent iodine reagent as the only oxidant. This unprecedented process encompasses not only two sequential CN/CO‐bond formations, but also the insertion of a carbonyl oxygen, all in one pot under metal‐free conditions.