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Pd 0 ‐Catalyzed Intramolecular α‐Arylation of Sulfones: Domino Reactions in the Synthesis of Functionalized Tetrahydroisoquinolines
Author(s) -
Solé Daniel,
PérezJaner Ferran,
Mancuso Raffaella
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201406305
Subject(s) - intramolecular force , domino , catalysis , intermolecular force , chemistry , combinatorial chemistry , michael reaction , cascade reaction , organic chemistry , molecule
A new strategy for the synthesis of tetrahydroisoquinolines based on the Pd 0 ‐catalyzed intramolecular α‐arylation of sulfones is reported. The combination of this Pd‐catalyzed reaction with intermolecular Michael and aza‐Michael reactions allows the development of two‐ and three‐step domino processes to synthesize diversely functionalized scaffolds from readily available starting materials.