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Asymmetric Conjugate Additions and Allylic Alkylations Using Nucleophiles Generated by Hydro‐ or Carbometallation
Author(s) -
Maksymowicz Rebecca M.,
Bissette Andrew J.,
Fletcher Stephen P.
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201405855
Subject(s) - nucleophile , conjugate , tsuji–trost reaction , scope (computer science) , allylic rearrangement , combinatorial chemistry , alkylation , chemistry , catalysis , computer science , organic chemistry , mathematics , mathematical analysis , programming language
This Minireview discusses catalytic asymmetric conjugate addition and allylic alkylation reactions where the nucleophiles were generated in situ by hydrometallation or carbometallation. This exciting recent trend in asymmetric catalysis promises to expand the range of transformations available for the rapid and selective assembly of complex, functional molecules for both academic and industrial research. This Minireview aims to serve as a reference for studies reported to date and discusses the current state‐of‐the‐art, scope and limitations of these processes.