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Hierarchical CaCO 3 Chromatography: A Stationary Phase Based on Biominerals
Author(s) -
Sato Kosuke,
Oaki Yuya,
Takahashi Daisuke,
Toshima Kazunobu,
Imai Hiroaki
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201405724
Subject(s) - hydrophilic interaction chromatography , macromolecule , chemistry , adsorption , molecule , phase (matter) , elution , biomineralization , column chromatography , chromatography , high performance liquid chromatography , chemical engineering , organic chemistry , biochemistry , engineering
In biomineralization, acidic macromolecules play important roles for the growth control of crystals through a specific interaction. Inspired by this interaction, we report on an application of the hierarchical structures in CaCO 3 biominerals to a stationary phase of chromatography. The separation and purification of acidic small organic molecules are achieved by thin‐layer chromatography and flash chromatography using the powder of biominerals as the stationary phase. The unit nanocrystals and their oriented assembly, the hierarchical structure, are suitable for the adsorption site of the target organic molecules and the flow path of the elution solvents, respectively. The separation mode is ascribed to the specific adsorption of the acidic molecules on the crystal face and the coordination of the functional groups to the calcium ions. The results imply that a new family of stationary phase of chromatography can be developed by the fine tuning of hierarchical structures in CaCO 3 materials.