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Masked Unsaturated Esters/Amides in Asymmetric Organocatalysis
Author(s) -
Monge David,
Jiang Hao,
AlvarezCasao Yolanda
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201405552
Subject(s) - organocatalysis , chemistry , catalysis , carboxylate , covalent bond , non covalent interactions , enantioselective synthesis , organic chemistry , combinatorial chemistry , simplicity , molecule , hydrogen bond , philosophy , epistemology
This Concept article summarizes strategies and developments regarding the use of masked unsaturated esters/amides in asymmetric organocatalysis. Useful substrates are categorized by the design of their inherent carboxylate template. This template group not only enables their functionality as ester surrogates, but also define their accessibilities, modes of interactions with catalysts and the simplicity with which they transform back to the parent carboxylates. Both covalent and noncovalent catalytic systems are discussed and examples showing the entire process (from substrates‐to‐functionalized ester/amides) are given.