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High Impact of Uranyl Ions on Carrying–Releasing Oxygen Capability of Hemoglobin‐Based Blood Substitutes
Author(s) -
Duan Li,
Du Lili,
Jia Yi,
Liu Wenyuan,
Liu Zhichao,
Li Junbai
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201405439
Subject(s) - uranyl , adsorption , oxygen , hemoglobin , nanoparticle , chemical engineering , materials science , iron oxide , microsphere , chemistry , nuclear chemistry , nanotechnology , ion , metallurgy , organic chemistry , engineering
The effect of radioactive UO 2 2+ on the oxygen‐transporting capability of hemoglobin‐based oxygen carriers has been investigated in vitro. The hemoglobin (Hb) microspheres fabricated by the porous template covalent layer‐by‐layer (LbL) assembly were utilized as artificial oxygen carriers and blood substitutes. Magnetic nanoparticles of iron oxide (Fe 3 O 4 ) were loaded in porous CaCO 3 particles for magnetically assisted chemical separation (MACS). Through the adsorption spectrum of magnetic Hb microspheres after adsorbing UO 2 2+ , it was found that UO 2 2+ was highly loaded in the magnetic Hb microspheres, and it shows that the presence of UO 2 2+ in vivo destroys the structure and oxygen‐transporting capability of Hb microspheres. In view of the high adsorption capacity of UO 2 2+ , the as‐assembled magnetic Hb microspheres can be considered as a novel, highly effective adsorbent for removing metal toxins from radiation‐contaminated bodies, or from nuclear‐power reactor effluent before discharge into the environment.