Premium
Synthesis, Culture Medium Stability, and In Vitro and In Vivo Zebrafish Embryo Toxicity of Metal–Organic Framework Nanoparticles
Author(s) -
Ruyra Àngels,
Yazdi Amirali,
Espín Jordi,
CarnéSánchez Arnau,
Roher Nerea,
Lorenzo Julia,
Imaz Inhar,
Maspoch Daniel
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201405380
Subject(s) - toxicity , in vivo , zebrafish , cytotoxicity , in vitro , chemistry , nanotoxicology , embryo , nanotechnology , microbiology and biotechnology , biophysics , biology , materials science , biochemistry , organic chemistry , gene
Abstract Metal–organic frameworks (MOFs) are among the most attractive porous materials available today. They have garnered much attention for their potential utility in many different areas such as gas storage, separation, catalysis, and biomedicine. However, very little is known about the possible health or environmental risks of these materials. Here, the results of toxicity studies on sixteen representative uncoated MOF nanoparticles (nanoMOFs), which were assessed for cytotoxicity to HepG2 and MCF7 cells in vitro, and for toxicity to zebrafish embryos in vivo, are reported. Interestingly, there is a strong correlation between their in vitro toxicity and their in vivo toxicity. NanoMOFs were ranked according to their respective in vivo toxicity (in terms of the amount and severity of phenotypic changes observed in the treated zebrafish embryos), which varied widely. Altogether these results show different levels of toxicity of these materials; however, leaching of solubilized metal ions plays a main role.