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Copper‐Catalyzed Reductive Cross‐Coupling of Nonactivated Alkyl Tosylates and Mesylates with Alkyl and Aryl Bromides
Author(s) -
Liu JingHui,
Yang ChuTing,
Lu XiaoYu,
Zhang ZhenQi,
Xu Ling,
Cui Mian,
Lu Xi,
Xiao Bin,
Fu Yao,
Liu Lei
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201405223
Subject(s) - alkyl , aryl , chemistry , catalysis , intramolecular force , coupling reaction , beta hydride elimination , copper , organic chemistry , medicinal chemistry , combinatorial chemistry
A copper‐catalyzed reductive cross‐coupling reaction of nonactivated alkyl tosylates and mesylates with alkyl and aryl bromides was developed. It provides a practical method for efficient and cost‐effective construction of aryl–alkyl and alkyl–alkyl CC bonds with stereocontrol from readily available substrates. When used in an intramolecular fashion, the reaction enables convenient access to various substituted carbo‐ or heterocycles, such as 2,3‐dihydrobenzofuran and benzochromene derivatives.