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Pd‐ and Cu‐Catalyzed Stereo‐ and Regiocontrolled Decarboxylative/CH Fluoroalkenylation of Heteroarenes
Author(s) -
Rousée Kevin,
Schneider Cédric,
CouveBonnaire Samuel,
Pannecoucke Xavier,
Levacher Vincent,
Hoarau Christophe
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201405119
Subject(s) - catalysis , biomolecule , combinatorial chemistry , chemistry , organic chemistry , biochemistry
Pd/Cu‐catalyzed decarboxylative/direct CH alkenylations of heteroarenes with α‐fluoroacrylic acid is reported. This method offers step‐economical and stereocontrolled access to valuable heteroarylated monofluoroalkenes as both Z and E isomers, which are known to be useful in the synthesis of fluorinated biomolecules.