Metal‐Free CN‐ and NN‐Bond Formation: Synthesis of 1,2,3‐Triazoles from Ketones,  N ‐Tosylhydrazines, and Amines in One Pot | Zendy

Chen Zhengkai | Zendy; Yan Qiangqiang | Zendy; Liu Zhanxiang | Zendy; Zhang  Yuhong | Zendy

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Metal‐Free CN‐ and NN‐Bond Formation: Synthesis of 1,2,3‐Triazoles from Ketones, N ‐Tosylhydrazines, and Amines in One Pot

Author(s) -

Chen Zhengkai,

Yan Qiangqiang,

Liu Zhanxiang,

Zhang Yuhong

Publication year - 2014

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201405057

Subject(s) - regioselectivity , chemistry , iodine , transition metal , medicinal chemistry , combinatorial chemistry , organic chemistry , catalysis

A novel synthetic approach toward 1,4‐disubstituted 1,2,3‐triazoles by CN‐ and NN‐bond formation has been established under transition‐metal‐free conditions. Complete control of the regioselectivity was successfully achieved. Commercially available anilines, ketones, and N ‐tosylhydrazine were treated with molecular iodine in one pot to allow the regioselective generation of 1,4‐disubstituted 1,2,3‐triazoles in high yields without the use of azides.

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