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Water‐Soluble Molecularly Imprinted Nanoparticles (MINPs) with Tailored, Functionalized, Modifiable Binding Pockets
Author(s) -
Awino Joseph K.,
Zhao Yan
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201404919
Subject(s) - chemistry , covalent bond , nanoparticle , molecular imprinting , binding site , imprinting (psychology) , covalent binding , micelle , combinatorial chemistry , molecularly imprinted polymer , binding selectivity , molecular binding , nanotechnology , selectivity , organic chemistry , molecule , biochemistry , materials science , aqueous solution , gene , catalysis
Construction of receptors with binding sites of specific size, shape, and functional groups is important to both chemistry and biology. Covalent imprinting of a photocleavable template within surface–core doubly cross‐linked micelles yielded carboxylic acid‐containing hydrophobic pockets within the water‐soluble molecularly imprinted nanoparticles. The functionalized binding pockets were characterized by their binding of amine‐ and acid‐functionalized guests under different pH values. The nanoparticles, on average, contained one binding site per particle and displayed highly selective binding among structural analogues. The binding sites could be modified further by covalent chemistry to modulate their binding properties.