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Palladium‐Catalyzed α‐Arylation of Arylketones at Low Catalyst Loadings
Author(s) -
Marelli Enrico,
Corpet Martin,
Davies Sian R.,
Nolan Steven P.
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201404900
Subject(s) - catalysis , palladium , aryl , ligand (biochemistry) , combinatorial chemistry , solvent , carbene , coupling (piping) , chemistry , organic chemistry , materials science , composite material , biochemistry , alkyl , receptor
A general catalytic protocol for the α‐arylation of aryl ketones has been developed. It involves the use of a preformed, bench‐stable Pd– N ‐heterocyclic carbene pre‐catalyst bearing IHept as an ancillary ligand, and allows the coupling of various functionalized coupling partners at very low catalyst loading. Careful choice of the solvent/base system was crucial to obtain optimum catalyst performance. The pre‐catalyst was also successfully tested in the synthesis of an industrially relevant compound.