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Asymmetric Reduction of α‐Amino Ketones with a KBH 4 Solution Catalyzed by Chiral Lewis Acids
Author(s) -
He Peng,
Zheng Haifeng,
Liu Xiaohua,
Lian Xiangjin,
Lin Lili,
Feng Xiaoming
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201404732
Subject(s) - enantioselective synthesis , catalysis , chemistry , lewis acids and bases , combinatorial chemistry , borohydride , amino acid , organic chemistry , reduction (mathematics) , mathematics , biochemistry , geometry
An efficient enantioselective reduction of α‐amino ketones with potassium borohydride solution catalyzed by chiral N,N′ ‐dioxide–metal complex catalysts was accomplished under mild reaction conditions for the first time. It provided a simple, convenient, and practical approaches for obtaining synthetically important chiral β‐amino alcohols in good to excellent yields (up to 98 %) and enantioselectivities (up to 97 % ee ).