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High Relaxivity Mn 2+ ‐Based MRI Contrast Agents
Author(s) -
RegueiroFigueroa Martín,
Rolla Gabriele A.,
EstebanGómez David,
de Blas Andrés,
RodríguezBlas Teresa,
Botta Mauro,
PlatasIglesias Carlos
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201404673
Subject(s) - molecule , chemistry , dipicolinic acid , human serum albumin , crystallography , solvent , derivative (finance) , coordination sphere , stereochemistry , organic chemistry , biochemistry , biology , botany , spore , financial economics , economics
Stable Mn 2+ mono‐ and binuclear complexes containing pentadentate 6,6′‐((methylazanediyl)bis(methylene))dipicolinic acid coordinating units give remarkably high relaxivities due to the presence of two inner‐sphere water molecules. The mononuclear derivative binds human serum albumin (HSA) with an association constant of 3372 M −1 , which results in the replacement of the coordinated water molecules by donor atoms of protein residues. The dinuclear analogue also binds HSA while leaving one of the Mn 2+ centres exposed to the solvent with two coordinated water molecules. Thus, this complex shows remarkably high relaxivities upon protein binding (39.0 m M −1 s −1 per Mn, at 20 MHz and 37 °C).