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Titanium cis ‐1,2‐Diaminocyclohexane ( cis ‐DACH) Salalen Catalysts for the Asymmetric Epoxidation of Terminal Non‐Conjugated Olefins with Hydrogen Peroxide
Author(s) -
Wang Qifang,
Neudörfl JörgM.,
Berkessel Albrecht
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201404639
Subject(s) - hydrogen peroxide , catalysis , conjugated system , chemistry , cyclohexane , enantiomer , solvent , medicinal chemistry , enantiomeric excess , titanium , enantioselective synthesis , organic chemistry , combinatorial chemistry , polymer
Chiral Ti salalen complexes catalyze the asymmetric epoxidation of terminal non‐conjugated olefins with hydrogen peroxide. Modular ligands based on cis ‐1,2‐diamino‐cyclohexane ( cis ‐DACH) were developed, giving high yields and enantiomeric excesses ( ee , up to 96 %) at catalyst loadings as low as 0.1–0.5 mol %, and even under solvent‐free conditions.