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[Au]/[Pd] Multicatalytic Processes: Direct One‐Pot Access to Benzo[ c ]chromenes and Benzo[ b ]furans
Author(s) -
Oonishi Yoshihiro,
GómezSuárez Adrián,
Martin Anthony R.,
Makida Yusuke,
Slawin Alexandra M. Z.,
Nolan Steven P.
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201404630
Subject(s) - chemistry , catalysis , heck reaction , selectivity , combinatorial chemistry , solvent , palladium , medicinal chemistry , organic chemistry
Abstract A new synthetic protocol that combines the advantages offered by eco‐friendly solvent‐free reactions and sequential transformations is reported. This strategy offers straightforward access to benzo[ c ]chromenes and benzo[ b ]furans from commercially available starting materials. This two‐step, one‐pot strategy consists of an Au‐catalyzed hydrophenoxylation process followed by Pd‐catalyzed CH activation or Mizoroki–Heck reactions. The selectivity of the process towards CH activation or Mizoroki–Heck reaction can be easily tuned.