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Synergistic Catalysis: Enantioselective Addition of Alkylbenzoxazoles to Enals
Author(s) -
Meazza Marta,
Ceban Victor,
Pitak Mateusz B.,
Coles Simon J.,
Rios Ramon
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201404565
Subject(s) - enantioselective synthesis , catalysis , stereoselectivity , chemistry , amine gas treating , lewis acids and bases , synergistic catalysis , combinatorial chemistry , chiral lewis acid , organic chemistry
A novel catalytic enantioselective methodology based on synergistic catalysis is reported. The strategy involves: 1) the metal‐Lewis‐acid activation of alkylazaarenes, and 2) the secondary‐amine activation of enals. Consequently, highly functionalized chiral alkylazaarenes were obtained in good yields and with reasonable stereoselectivity.