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Palladium‐Catalyzed Carbonylation of 2‐Bromoanilines with 2‐Formylbenzoic Acid and 2‐Halobenzaldehydes: Efficient Synthesis of Functionalized Isoindolinones
Author(s) -
Natte Kishore,
Chen Jianbin,
Li Haoquan,
Neumann Helfried,
Beller Matthias,
Wu XiaoFeng
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201404446
Subject(s) - carbonylation , palladium , catalysis , chemistry , combinatorial chemistry , organic chemistry , carbon monoxide
A concise and highly versatile method for the synthesis of functionalized isoindolinones is reported. Various 2‐bromoanilines undergo palladium‐catalyzed carbonylation with 2‐formylbenzoic acid under a convenient and mild procedure to give good to excellent yields of the corresponding isoindolinones. Additionally, 2‐halobenzaldehydes can be applied as substrates in palladium‐catalyzed double‐carbonylation to provide identical compounds in moderate to good yields.