Copper‐Catalyzed Intramolecular Carbotrifluoromethylation of Alkynes for the Construction of Trifluoromethylated Heterocycles | Zendy

Wang Yanan | Zendy; Jiang Min | Zendy; Liu JinTao | Zendy

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Copper‐Catalyzed Intramolecular Carbotrifluoromethylation of Alkynes for the Construction of Trifluoromethylated Heterocycles

Author(s) -

Wang Yanan,

Jiang Min,

Liu JinTao

Publication year - 2014

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201404386

Subject(s) - intramolecular force , reagent , chemistry , copper , catalysis , combinatorial chemistry , trifluoromethylation , functional group , intramolecular reaction , organic chemistry , trifluoromethyl , alkyl , polymer

A mild and efficient copper‐catalyzed intramolecular carbotrifluoromethylation of alkynes has been achieved in the presence of Togni reagent as trifluoromethylating reagent. The reaction tolerates a range of substrates to give a group of trifluoromethylated heterocycles with high selectivities. A plausible mechanism was proposed on the basis of experimental results.

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