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Copper‐Catalyzed Intramolecular Carbotrifluoromethylation of Alkynes for the Construction of Trifluoromethylated Heterocycles
Author(s) -
Wang Yanan,
Jiang Min,
Liu JinTao
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201404386
Subject(s) - intramolecular force , reagent , chemistry , copper , catalysis , combinatorial chemistry , trifluoromethylation , functional group , intramolecular reaction , organic chemistry , trifluoromethyl , alkyl , polymer
A mild and efficient copper‐catalyzed intramolecular carbotrifluoromethylation of alkynes has been achieved in the presence of Togni reagent as trifluoromethylating reagent. The reaction tolerates a range of substrates to give a group of trifluoromethylated heterocycles with high selectivities. A plausible mechanism was proposed on the basis of experimental results.