Premium
Enantiopure Isoindolinones through Viedma Ripening
Author(s) -
Steendam René R. E.,
Brouwer Maxime C. T.,
Huijs Evelien M. E.,
Kulka Michaël W.,
Meekes Hugo,
van Enckevort Willem J. P.,
Raap Jan,
Rutjes Floris P. J. T.,
Vlieg Elias
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201404320
Subject(s) - enantiopure drug , catalysis , ripening , dissolution , chemistry , organic chemistry , enantioselective synthesis , food science
Abstract Here we demonstrate that deracemization of isoindolinones using Viedma ripening is possible starting from a racemic mixture of conglomerate crystals. Crystals of the enantiopure isoindolinones lose their chiral identity upon dissolution even without the need for a catalyst. This enabled complete deracemization of the reported isoindolinones without a catalyst.